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Liposomal Encapsulation Technology For a Food Supplement Alternative

The market has several types of food supplements, making it difficult to choose one that does exactly what it says. It is no secret that we believe in the power of liposomal formulations and the value it adds to our lives. This article might help you decide why food supplements enhanced by liposomal encapsulation technology could be right for you.

Food supplements Explained & Why We Need Them

Food supplements are the consumption of nutrients in a concentrated, dose form, outside of our regular diets [1,2]. A dose form indicates the measured dose of a nutrient in the form of tablets, syrups or capsules that we ingest. As we mentioned in our 'Why Do We Need Food Supplements?' blog, our bodies cannot synthesize a lot of the essential nutrients we need. Ageing, disease, heavy physical activity and improper and imbalanced diets lead to deficiencies. Food supplementation is thus, an essential for a majority of the world’s population.

The Available Forms of Food Supplements

“Food supplements can be categorized based on the type or source of the active ingredient.”

One way to categorize food supplements is on the type of active ingredient. Food supplements are thus categorized as proteins, vitamins and minerals. Another form of categorization is by using the nature of the source ingredients. We can then, therefore, classify food supplements in the following manner:

1. Natural Food Supplements

Natural food supplement ingredients come from plant, animal or microbial sources. These natural extracts are then packaged in their unmodified form. including ingredients such as curcumin, bovine collagen and resveratrol in PlantaCorp's line of products.

2. Semi-synthetic Food Supplements

Semi-synthetic supplements are typically derived from natural sources but are then chemically modified. The modification of ingredients is necessary, in some cases, in order to allow the body to process the ingredients. These modifications aim to obtain a biologically active or biologically available form. The proposed modifications of fat-soluble vitamins such as Vitamin K or Vitamin A, so that they become water-soluble, is an example [3].

3. Synthetic Food Supplements

A synthetic supplement is a wholly artificially food supplement. This is beneficial in cases where the natural source may be scarce or unavailable. We chemically synthesize most of our B vitamins.

Disadvantages Of Current Food Supplements

Widely consumed supplements are typically known as “traditional” food supplements. The manufacturing process of these supplements uses well-established and/or traditional technologies. These supplements have the goal of complementing or completing your daily nutrient intake. However, the majority of current food supplements do not deliver their full dose. This is true for healthy individuals as well.

Why traditional food supplements can't deliver their full dose

Current food supplements typically contain higher than the daily required dose of a nutrient. However, even with this higher-than-required dose, the human body can only absorb a usually lower limit of nutrient. Our bodies eliminate the rest of the unabsorbed nutrients through urine or feces. Another reason for the inefficacy of some food supplements is that they are easily destroyed by the enzymes in saliva or by our stomach acid. This happens even before absorption by the intestine for delivery into the bloodstream. The third reason for their inefficacy is that many nutrients are poorly water-soluble. This means that they will require a carrier protein or fat to be able to delivered to their site of action.

“Traditional food supplements are mostly inefficient because of overloading, destruction by the digestive system and poor water solubility.”

Liposome-encapsulated food supplements

Typical phospholipid and liposome structure

An emerging trend in the market is liposome-encapsulated food supplements. Liposomes are man-made, phospholipid bilayer spheres. A phospholipid molecule, like a fat molecule, comprises of two hydrophobic (water-repelling) lipid tails. However, they also contain a hydrophilic (water-loving) phospho head. Thus, when arranged as a bilayer (two layers) sphere such that the heads face outside and the lipids face each other, the liposome is water-soluble.

Our body’s cell membranes are naturally made of phospholipid bilayers. In order to make phospholipids into liposomes outside of the body, we need to provide energy to the system. This is why liposomes are man-made.

The advantages of liposome-encapsulated food supplements compared to traditional food supplements

“Liposomes can effectively deliver fat-soluble and water-soluble nutrients to the blood stream.”

Encapsulation of nutrients in a liposome

Liposomes are able to encapsulate both water-soluble and fat-soluble substances within the sphere. This is thanks to having an aqueous (water) core and a lipid bilayer surrounding it. Once encapsulated, they can deliver an active ingredient safely to the bloodstream [4]. The protection of the active ingredient ensures that it can safely cross biological barriers such asthe acidic environment of the stomach. Further, fat-soluble nutrients such as curcumin, are better absorbed by the body when accompanied by lipid molecules [5]. Finally, we require a lower dose of the ingredient thanks to the increased availability of nutrients in the bloodstream. This ensures that the body only eliminates a very small percentage of the nutrient. Maximum absorption of a nutrient thus means, maximum nutritional effect.

The disadvantages of liposome-encapsulated food supplements compared to traditional food supplements

As such, there are no known disadvantages of plant-based liposomes as they are biocompatible. They are non-toxic and are easily eliminated from our body by macrophages [6].

One of the limiting factors for liposomal formulations is cost. Liposomal formulations are a little bit more expensive than traditional food supplements of the same dosage because they are a new technology. However, with the increased adoption of liposomal food supplements, we foresee that this difference will soon be a thing of the past. Further, as outlined above, the nutritional advantages far exceed the current cost limitations.

Key takeaways Liposomal Encapsulation Technology For a Food Supplement Alternative

  • Traditional food supplements are those manufactured using well-established practices.

  • Traditional food supplements do not always complete our normal diets. They suffer from problems of overloading, destruction by the digestive system and poor water solubility.

  • Liposomal formulations are an emerging category of food supplements. Liposomes are phospholipid bilayer spheres capable of encapsulating both water-soluble and fat-soluble nutrients.

  • Liposome-encapsulated food supplements have several advantages over traditional food supplements. They can protect their contents from gastric destruction thus effectively being able to deliver almost all their content into the bloodstream.



  2. The National Institutes of Health: Office of Dietary Supplements. Dietary supplement fact sheets.

  3. Hirota Y & Suhara Y. New Aspects of Vitamin K Research with Synthetic Ligands: Transcriptional Activity via SXR and Neural Differentiation Activity. Int J Mol Sci. (2019); 20 (12): 3006.

  4. Shade CW. Liposomes as Advanced Delivery Systems for Nutraceuticals. Integr Med (Encinitas). 2016;15(1):33–36.

  5. Stohs SJ, Chen O, Ray SD et al. Highly Bioavailable Forms of Curcumin and Promising Avenues for Curcumin-Based Research and Application: A Review. Molecules (2020); 25: 1397.

  6. Porter CJH, Trevaskis NL and Charman WN. Lipids and lipid-based formulations: optimizing the oral delivery of lipophilic drugs. Nature Reviews (2007); 6: 231–248.

  7. Liposomal Food SupplementsInforming decisions on food supplements, with a special focus on liposomal food technology. Follow


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